Search results for " alpha 1-Antitrypsin"

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Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2

2021

Protein accumulation is the hallmark of various neuronal, muscular, and other human disorders. It is also often seen in the liver as a major protein-secretory organ. For example, aggregation of mutated alpha1-antitrypsin (AAT), referred to as PiZ, is a characteristic feature of AAT deficiency, whereas retention of hepatitis B surface protein (HBs) is found in chronic hepatitis B (CHB) infection. We investigated the interaction of both proteotoxic stresses in humans and mice. Animals overexpressing both PiZ and HBs (HBs-PiZ mice) had greater liver injury, steatosis, and fibrosis. Later they exhibited higher hepatocellular carcinoma load and a more aggressive tumor subtype. Although PiZ and H…

0301 basic medicineCirrhosisNF-E2-Related Factor 2medicine.disease_causePathology and Forensic MedicineMice03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingStress PhysiologicalFibrosisSequestosome-1 ProteinmedicineAnimalsHumansLiver injuryHepatitis B Surface Antigensbusiness.industryLiver DiseasesAutophagyHepatitis Bmedicine.diseasedigestive system diseasesaggregate Hepatitis B Surface Antigens Humans Liver Diseases Mice NF-E2-Related Factor 2 Sequestosome-1 Protein Stress Physiological alpha 1-Antitrypsin cirrhosis inclusionlipophagy oxidative stress SERPINA1 Animals030104 developmental biologyalpha 1-Antitrypsin030220 oncology & carcinogenesisHepatocellular carcinomaCancer researchSteatosisbusinessOxidative stressThe Journal of Pathology
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Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics

2003

In asthmatic subjects an imbalance between elastase and alpha1-antitrypsin (alpha1-PI) exists. This study aims to evaluate whether ageing per se affects the levels of elastase. Both young and elderly asthmatics with comparable severity and duration of disease, as well as young and elderly healthy subjects, underwent an induced sputum procedure to measure levels of elastase and alpha1-PI. The percentage of sputum neutrophils and eosinophils was higher in young and elderly asthmatics than in young and elderly controls. The levels of both total and active elastase were significantly higher in young and elderly asthmatics than in young and elderly controls, and directly correlated with the perc…

Pulmonary and Respiratory MedicineAdultmedicine.medical_specialtySputum CytologyPathologyAgingNeutrophilsDiseaseEosinophilSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyLeukocyte CountInternal medicineForced Expiratory VolumeMedicineHumansAsthmaAgedPancreatic Elastasebusiness.industryRespiratory diseaseElastaseNeutrophilSputumsocial sciencesMiddle Agedmedicine.diseasehumanitiesPathophysiologyAsthmaEosinophilsAgeingalpha 1-AntitrypsinAdult; Aged; Aging; Asthma; Eosinophils; Forced Expiratory Volume; Humans; Leukocyte Count; Middle Aged; Neutrophils; Pancreatic Elastase; Sputum; alpha 1-AntitrypsinSputummedicine.symptombusinessHuman
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